Public Transportation by bus from Panama City to Los Islotes is an option but it is going to take longer than 5 hours because of all the passenger stops the bus makes along the way.  From the Tocumen International Airport you would take a $35.00 cab ride to the Albrook bus terminal.  From Albrook you would take a bus to Santiago.  The bus ride from Albrook to Santiago takes on average 4 hours and costs in the neighborhood of $9.00.  In Santiago you would catch a bus to Quebro. The buses from Santiago to Quebro run once in the morning and once in the afternoon.  The bus ride from Santiago to Quebro takes on average 5 hours and costs in the neighborhood of $3.00.